111. Physical Chemistry. (4.5 units) Fa. Prerequisites: None. Restrictions: First year Pharmacy students; others by permission of instructor. Lecture 4 hours.
M. Jacobson, T. James
This course teaches the fundamentals of thermodynamics, chemical kinetics, and enzyme kinetics, along with their application to biochemical and pharmaceutical systems, including drug discovery and design.
113. Advanced Organic Chemistry. (3 units) Wi. Lecture 3 hours.
S. Miller
This course lays the foundation for understanding drug action in terms of specifuc interactions between drug molecules and biological targets. It focuses on the chemical and structural properties of the major biological macromolecules that interact with drugs.
114. Intro to Pharm Chem & Drug Metabolism. (3 units) Sp. Prerequisites: Pharm Chem 113. Lecture 3 hours.
P. Ortiz de Montellano, S. Miller
A study of physicochemical and biological factors which contribute to drug action; in vivo and in vitro biotransformations of drugs and related organic compounds.
121. Endocrine & Immunologic Agents. (3 units) Fa. Prerequisites: Biochemistry 112 and Pharmaceutical Chemistry 113. Physiology 121 or concurrent enrollment. Lecture 3 hours.
S. Kahl
The basic focus of this course is consideration of structure-function relationships in various drug classes and their antagonists involved in the treatment of endocrine diseases and in the inhibition of inflammation and immune response. The course is closely coordinated with Pharmacology 121.
122. Cardiovascular & Autonomic Agents. (2 units) Wi. Prerequisites: Biochemistry 112, Pharmaceutical Chemistry 113 and Physiology 121. Lecture 2 hours.
C. Wang
This course provides a systematic survey of the chemical features of synthetic drugs acting on the autonomic and cardiovascular systems, and emphasizes correlations between chemical structure and biological activity.
123. Drugs of the CNS. (2 units) § Sp. Prerequisites: Consent of instructor. Lecture 2 hours.
N. Oppenheimer
This course emphasizes the structure and mechanism of drugs whose primary effects are on the central nervous system. These include: antipsychotics, antidepressants, sediative hypnotics, anticonvulsants, antipiletics, stimulants, drugs of abuse, antiparkinson's drugs, anesthetics, and neurodegenerative diseases.
131. Antibiotics and Anticancer Drugs. (2.5 units) § Fa. Prerequisites: Third-year standing in School of Pharmacy, PharmD program or consent of instructor. Lecture 2 hours.
N. Oppenheimer
This course focuses on the structure, properties and mechanism of drugs used in antibacterial, antifungal, antiparasitic, antiviral and anticancer therapies. Emphasis is also placed on mechanisms of resistance and means of avoiding or circumventing resistance.
152. Drug Discovery & Design. (3 units) Sp. Prerequisites: Chemistry 113. Lecture 3 hours.
B. Shoichet
Principles of how new drug are discovered with emphasis on the drug disccovery pipeline, target identification, screening methodologies and assays, mechanism-based design, structure-based design, in vitro and in vivo testing, chemical analoging and development issues. Connections to genomics, pharmacogenetics, bioinformatics, pharmacokinetics and pharmacodynamics, immunology and parasitology and appropriate health science, pharmaceutical industry and clinical issues will be discussed.
157. Bioanalytical Theory & Technique. (3 units) Sp. Prerequisites: Spring quarter of third year School of Pharmacy standing or membership in approved graduate program or consent of instructor. Lecture 2 hours. Laboratory 3 hours.
S. Kahl
Course covers the theoretical basis, experimental approach and practical aspects of the detection and quantification of drugs and their metabolites in biological samples. Topics include solubility groups, liquid-liquid extractions and sample preparation, spectrophotometric techniques, mass spectrometry, chromatographic theory and techniques, competitive protein binding assays, protein separation, and DNA analysis and sequencing techniques. Laboratory project in a selected area.
158. Research Administration. (2 units) Fa. Prerequisites: Pharmacy students must have completed their 3rd year of professional courses or have the consent of the instructor. Restrictions: None. Lecture 2 hours.
R. Shafer
This course is designed to introduce students to the important aspects of research administration and the components that help assure a successful research program. The course covers grant submission, budget development, allocation of resources, consideration of regulatory affairs, ethical issues important for research and the dissemination of research findings.
163. Pharmaceutical Sciences Pathway Seminar. (1 units) Fa, Wi. Prerequisites: Completion of BPS 134. Restrictions: Pharmaceutical Science Pathway students in the PharmD program. Seminar 30 hours.
R. Shafer
Pharmaceutical Science Pathway students will take turns either presenting a journal article or their research progress, with discussion expected from all participants. In advance of each lecture, an abstract will be posted for all students to read, along with at least one article. Two classes each quarter will be presented by faculty on their own research and/or research opportunities.
165. Pharmacuetical Sci. Pathway Project: Pharmacuetical Chemistry. (4-10 units) Su, Fa, Wi, Sp, SS1, SS2, SS3. Prerequisites: Successful completion of BIOPHRM SC 134 Research Design. Restrictions: Pharmacy students must have completed their 3rd year of professional courses or consent of instructor. Independent Study 12-30 hours.
S. Kahl
This course is designed to introduce students to research. Students will work closely with a member of the faculty and will focus on a specific project. Students will write a grant for protocol summarizing the work planned, carry out hands-on aspects of the research, analyze results and present findings.
170. Group Studies. (1-4 units) § Fa, Wi, Sp, SS1, SS2, SS3. Prerequisites: Consent of instructor and adviser. Seminar 3-12 hours.
Staff
Group studies of selected topics in pharmaceutical chemistry.
198. Supervised Study. (1-5 units) Fa, Wi, Sp, SS1, SS2, SS3. Library 3-15 hours.
Staff
Library research and directed reading under supervision of a member of the faculty with the approval of the chairperson of the department.
199. Laboratory Project. (1-5 units) Fa, Wi, Sp, SS1, SS2, SS3. Project 3-15 hours.
Staff
A laboratory research project under direction of a member of the faculty with the approval of the chairperson of the department.
204. Introduction to Object-Oriented Programming. (2 units) § Fa. Prerequisites: None. Restrictions: Permission of Instructor. Lecture 2 hours.
C. Huang, T. Ferrin
An introduction to object-oriented programming using the Python programming language. During the course, students learn to write, test, and debug programs of increasing complexity. Emphasis is on basic principles in writing well-structured and modular codes. Additional details available on course website: http://www.cgl.ucsf.edu/Outreach/pc204
206. Laboratory Rotation in Pharmaceutical Chemistry. (1-6 units) § Fa, Wi, Sp. Prerequisites: Consent of instructor. Laboratory 9 hours. Project 1-6 hours.
Staff
A laboratory rotation course to familiarize new students in the Graduate Program in Chemistry and Chemical Biology with various approaches to research in the pharmaceutical sciences.
219. Enzyme Mechanisms. (3 units) § Sp. Lecture 3 hours.
S. Miller
In-depth examination of specific enzyme reactions or systems, with emphasis on structure-function.
220. Research Conf in Pharmaceutics. (1 units) § Fa, Wi, Sp. Conference 1 hours.
F. Szoka
A program involving the presentation of core material in pharmaceutical chemistry in the pharmaceutics pathway. The presentations are made by graduate students and examination is by a series of cumulative examinations.
221. Research Conf in Chem, Chem Biol & Biophysics. (1 units) § Fa, Wi, Sp, SS1, SS2, SS3. Prerequisites: Graduate standing in the Department of Pharmaceutical Chemistry. Conference 1 hours.
T. James
A series of weekly research conferences in chemistry, chemical biology and biophysics given by visiting lecturers and faculty.
223. Scientific Communication Seminar. (1 units) § Fa, Wi, Sp. Seminar 1 hours.
C. Craik
This seminar will provide graduate students with a forum in which to develop seminar and poster presentation skills; critically organize and critically review scientific data; and analyze and question oral scientific presentations.
225. Graduate Research Opportunities. (1 units) § Fa, Wi, Sp. Prerequisites: Graduate standing in the Department of Pharmaceutical Chemistry. Seminar 1 hours.
B. Shoichet
A series of weekly presentations of the research interests of the basic science faculty. The purpose is to acquaint new graduate students with the research in the Departments of Pharmacy and Pharmaceutical Chemistry.
230. Fundamentals of Nuclear Magnetic Resonance. (3 units) § Wi. Prerequisites: None. Restrictions: None. Lecture 3 hours. Laboratory 4 hours.
M. Kelly
The course reviews practical applications on NMR spectroscopy to chemical and biological studies of small molecules and macromolecules. Course at an introductory graduate level, designed to be taken by researchers without prior NMR experience. Concepts covered include physical principles and theory relevant to modern NMR spectroscopy. Small group sessions will be conducted at a spectrometer console, ultimately enabling students to run standard experiments independently.
231. Nuclear Magnetic Resonance. (3-4 units) § Sp. Prerequisites: undergraduate physics or physical chemistry. Lecture 3 hours.
Staff
Theory and application of nuclear magnetic resonance for biomolecular structure determination.
235. Mass Spectrometry in Life Sci. (2 units) § Sp. Prerequisites: Consent of instructor. Lecture 2 hours.
A. Burlingame
Elucidation of molecular structure, characterizations of mixtures, and quantitative measurements. A presentation of basic tools, concepts, and strategies in the complementary usage of currently available techniques in present biochemical and biomedical research.
250. Research. (1-8 units) § Fa, Wi, Sp, SS1, SS2, SS3. Conference 1 hours. Project 3-24 hours.
Staff
266. Research Planning Conference. (1 units) § Fa, Wi, Sp, SS1, SS2, SS3. Prerequisites: Consent of instructor. Conference 1 hours.
Staff
Discussion and practice in research problem formulation and design selection. Core classes and small group sessions are organized around students' interests by faculty within the area of specialization.
298. Thesis. (0 units) § Fa, Wi, Sp, SS1, SS2, SS3. Prerequisites: Advancement to candidacy and permission of the graduate adviser.
Staff
For graduate students engaged in writing the thesis for the master's degree.
299. Dissertation. (0 units) § Fa, Wi, Sp, SS1, SS2, SS3. Prerequisites: Advancement to candidacy and permission of the graduate adviser.
Staff
For graduate students engaged in writing the dissertation for the PhD degree.
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