111

Biopharmaceutics

(3.5 units)

Fall

Instructor(s):X. Chen Prerequisite(s): First-year standing in School of Pharmacy.

Restrictions:None Activities: Lecture: 30 hours, Conference: 10 hours

This course is meant to introduce students to basic pharmacokinetic and biopharmaceutic principles. Pharmacokinetic concepts will first be introduced, including the concepts of clearance and volume of distribution as they relate to drug concentration-time relationships for common routes of administration. The second half of the course will focus on biopharmaceutics -- how drugs get to the site of absorption, drug dissolution, membrane permeability, bioavailability and bioequivalence. (BIO THERAP)

112

Biostatistics

(2.5 units)

Fall

Instructor(s):L. Floren

Activities: Lecture: 2 hours, Conference: 1 hours

This course is an introductory course in biostatistics covering topics such as elementary probability theory, hypothesis testing, analysis of variance, t-tests, Z- and chi-square tests, regression and correlation, nonparametric methods, estimation and confidence intervals, and computer-aided solutions. (BIO THERAP)

113

Drug Delivery: From Biologics to Devices

(3.0 units)

Spring

Instructor(s):T. Desai, P. Babbitt, T. Kortemme, F. Szoka, S. Roy Prerequisite(s): BIOPHRM SC 111

Restrictions:First year PharmD students. Activities: Lecture: 30 hours

This course will introduce pharmacy students to the principles of protein structure relevant to developing them as drugs and drug targets. They will also learn about the various routes and delivery systems for administration of drugs. Additionally, they will gain exposure into the imaging modalities used for evaluating these drugs, and the role of medical devices in enhancing therapy. (BIO THERAP)

115

Genetics and Pharmacogenetics

(2 units)

Spring

Instructor(s):S. Guo, E. Burchard, D. Kroetz Prerequisite(s): Concurrent enrollment in BPS 113 and 114 or permission of instructor

Restrictions:None. Activities: Lecture: 2 hours, Conference: 1 hours

This is a course to introduce pharmacy students to the basic principles of genetics and apply them to pharmacogenetics. (BIO THERAP)

121

Pharmacokinetic Variability

(0.0 - 2.5 units)

Fall

Instructor(s):D. Kroetz Prerequisite(s): Biopharmaceutical Sciences 111 and 113.

Activities: Lecture: 0 - 20 hours, Workshop: 0 - 10 hours

This course is meant to introduce the second year students to the primary determinants of pharmacokinetic variability, including 1) the influence of pharmacogenomics as well as induction and inhibition of drug metabolism and transport on variability in drug clearance and bioavailability, and 2) physiologic determinants of variability including age, body composition, renal and hepatic disease. (BIO THERAP)

122

Clinical Pharmacokinetics

(3 units)

Winter

Instructor(s):X. Chen, L. Floren, M. Winter Prerequisite(s): Biopharmaceutical Sciences 121.

Activities: Lecture: 2 hours, Conference: 2 hours

A continuation of Biopharmaceutical Sciences 121 in which student pharmacists will learn the sources of variability in the body's handling of drugs and how these influence kinetics and dosing of drugs. (BIO THERAP)

132

Drug Development Sciences

(2 - 3 units)

Winter

Instructor(s):D. Kroetz

Activities: Lecture: 4 hours, Project: 4 hours

This course focuses on the areas of drug metabolism, delivery and transport as they pertain to the area of new drug design and development. (BIO THERAP)

133

Pharmacokinetics in Drug Development

(3 units)

Spring

Instructor(s):F. Aweeka Prerequisite(s): Satisfactory completion of BPS 122.

Activities: Lecture: 2 hours, Project: 2 hours

The course will provide advanced training in pharmacokinetics with a focus on the issues involved with drug development. (BIO THERAP)

134

Research Design & Statistics in Drug Development

(3 units)

Winter

Instructor(s):N. Sambol Prerequisite(s): None.

Restrictions:This course is required for students in the Pharmaceutical Sciences Pathway, but is open to all students as an elective if space permits. Activities: Lecture: 2 hours, Project: 3 hours

This course covers detailed aspects of optimizing research design for clinical and basic research. The material presented builds on the content covered in the Study Design Course of the first year curriculum. Design strategies for varying types of research as well as skills for critical evaluation of research studies and literature will be the primary focus. In addition, the ethics of using animals and humans will be discussed. (BIO THERAP)

135

Principles of Pharmacogenomics

(3 units)

Spring

Instructor(s):N. Ahituv Prerequisite(s): None.

Restrictions:None. Activities: Lecture: 2 hours, Conference: 2 hours

This course provides students with a comprehensive overview of the genetic basis for differences in drug response. Genetic variability in drug receptors, transporters and enzymes as well as regulatory proteins involved in promoting and inhibiting transcription and translation will be discussed. The course also covers toxicogenetics and an introduction to computational genomics. (BIO THERAP)

165

Pharmaceutical Sci. Pathway Project: Biopharmaceutical Sciences

(4 - 10 units)

Fall, Winter, Spring, Summer

Instructor(s):S. Kahl Prerequisite(s): Successful completion of BIOPHRM SC 134 Research Design.

Restrictions:Pharmacy students must have completed their 3rd year of professional courses or consent of instructor. Activities: Independent Study: 12 - 30 hours

This course is designed to introduce students to research. Students will work closely with a member of the faculty and will focus on a specific project. Students will will write a grant for protocol summarizing the work planned, carry out hands-on aspects of the research, analyze results and present findings. (BIO THERAP)

198

Supervised Study in Biopharmaceutical Sciences

(1 - 5 units)

Fall, Winter, Spring, Summer

Instructor(s):Staff

Activities: Laboratory: 2 hours, Seminar: 1 hours

Library research and directed reading under supervision of a member of the faculty with the approval of the chairperson of the department. (BIO THERAP)

199

Laboratory Project in Biopharmaceutical Sciences

(1 - 5 units)

Fall, Winter, Spring, Summer

Instructor(s):Staff

Activities: Laboratory: 2 hours, Seminar: 1 hours

A laboratory research project under direction of a member of the faculty with the approval of the chairperson of the department. (BIO THERAP)

272A

Advanced Drug Delivery: Controlled and Targeted Drug Delivery

(2 units)

§

Winter

Instructor(s):F. Szoka Prerequisite(s): Chemistry 241 or equivalent.

Activities: Laboratory: 0 - 6 hours, Project: 0 - 1 hours

The focus of this course is on the chemical, biophysical and biological factors that impact on targeted and controlled drug delivery systems. There is a particular emphasis on colloidal systems and systems that provide a regulated controlled release. (BIO THERAP)