201A

Basic Concepts in Cellular and Molecular Neuroscience

(6 units)

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Fall

Instructor(s):J. Lansman, J. Lansman, E. Huang Prerequisite(s): None.

Restrictions:This course is required for first year Neuroscience students. It is open to additional students as space allows and with the approval of the instructor. Activities: Lecture: 3 hours, Seminar: 18 hours

An interdisciplinary introduction to fundamental aspects of nervous system function including neurocytology, neuroanatomy, electrical excitability, synaptic transmission, signal transduction, genetics, and neurodevelopment. (PHYSIOLOGY)

201B

Introduction to Systems and Behavioral Neuroscience

(4 units)

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Winter

Instructor(s):M. Brainard

Activities: Lecture: 3 hours, Conference: 1 hours

Introduction to fundamental aspects of nervous system development, including neural determination, axon guidance, neuron-target interactions and overview of basics of integrative neural function, including sensory, motor and limbic systems and computational neuroscience. (PHYSIOLOGY)

201C

Basic Concepts in Neural Development and Cell Biology

(4 units)

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Spring

Instructor(s):H. Baier, L. Reichardt Prerequisite(s): NC201A and NC201B or consent of course director.

Restrictions:None. Activities: Lecture: 4 hours, Conference: 1 hours

An overview of basic cell biology and neural development. Topics will include membrane trafficking, neuronal cytoskeleton, axon guidance, synapse formation, cell cycle, neuronal cell fate determination, neuronal stem cells, and patterning of the vertebrate brain. (PHYSIOLOGY)

214

Ethics and the Responsible Conduct of Research

(2 units)

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Spring

Instructor(s):B. Conklin Prerequisite(s): None.

Restrictions:None. Activities: Lecture: 4 hours

This course will cover topics related to the responsible conduct of research such as conflicts of interest, responsible authorship, policies regarding the use of human and animal subjects, handling misconduct, proper datat management, research funding rules and procedures. Students will review and present case studies for class discussion. (NEURSC PRG)

215

Laboratory Rotation

(1 - 6 units)

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Fall, Winter, Spring, Summer

Instructor(s):Staff Prerequisite(s): Consent of instructor.

Activities: Laboratory: 3 - 18 hours

A laboratory rotation course to familiarize new departmental graduate students with various approaches to neurobiological research. (PHYSIOLOGY)

219

Special Topics in Basic and Translational Neuroscience

(3 units)

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Fall, Winter, Spring

Instructor(s):Staff Prerequisite(s): None. Completion of first year curriculum in Neuroscience or another experimental biology graduate program is helpful, but not essential.

Restrictions:Neuroscience graduate students, other graduate and professional students with interest in neuroscience. Permission from instructor is required. Activities: Lecture: 1 hours, Conference: 2 hours, Independent Study: 3 hours

Each course offering will focus on the literature of a current important area of Neuroscience research. Students will be expected to read assigned papers critically before class and to present and discuss papers in class. Students will also be expected to write and present a brief research proposal based upon their reading. Topics in molecular, cellular, developmental, systems & computational neuroscience, and neurological & behavioral disorders will be covered in separate course offerings. (PHYSIOLOGY)

220

Neuroscience Journal Club

(1 units)

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Fall, Winter, Spring, Summer

Instructor(s):L. Reichardt

Activities: Seminar: 1 hours

Pertinent papers from the recent neuroscience literature are read and discussed. Each student must participate regularly and present one seminar per quarter. (PHYSIOLOGY)

221

Current Topics in Neuroscience

(0 - 3 units)

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Fall, Winter, Spring

Instructor(s):Y. Fu, Y. Fu Prerequisite(s): None.

Restrictions:Neuroscience graduate student, or permission from instructor. Activities: Seminar: 9 hours

Students will become familiarized with cutting-edge experimental findings in cellular, molecular, and systems neuroscience by attending the formal Neuroscience Seminar series, meeting and discussing related papers, and meeting with the speaker, Students will be expected to critically analyze new results and put them in context of published literature. Course meets for 10 weeks spread out over 3 quarters. Offered every year. (NEURSC PRG)

222

Signaling in Neurobiology

(3 units)

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Fall

Instructor(s):M. Von Zastrow Prerequisite(s): Neuroscience 201A and 201B, or consent of instructor.

Activities: Seminar: 3 hours

This course will explore molecular mechanisms of receptor, ion channel, and transport function and regulation. Topics may include second mesengers G-coupled pathways, tyrosine kinase pathways, serpentine receptor pathways, apoptosis, neurotrophic factors and cytoskeleton. Offered every three years beginning Spring 2002. (PHYSIOLOGY)

223

Developmental Neurobiology

(3 units)

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Fall

Instructor(s):S. Pleasure Prerequisite(s): Neuroscience 201A and 201B, or consent of instructor.

Activities: Lecture: 3 hours

This course will cover important areas of vertebrate and invertebrate nervous system development. It will integrate findings from anatomical cellular, molecular and genetic approaches. Topics may include neural induction, regionalization of the neural plate and neural tube, cell-type specification, proliferation, apoptosis morphogenesis, neurogenesis, gliogenesis, migration, differentiation, axon pathfinding, dendritogenesis, synaptogenesis. Offfered every three years beginning Fall 2001. (PHYSIOLOGY)

225

Neurobiology of Disease

(3 units)

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Spring

Instructor(s):S. Finkbeiner Prerequisite(s): Neuroscience 201A and 201B, or consent of instructor.

Activities: Seminar: 3 hours

Lectures and student-led discssions on physiological and molecular bases of diseases such as Alzheimer's, Parkinson's, multiple sclerosis, epilepsy, autism, addiction, triple repeat and prion diseases. Offered every three year beginning Spring 2003 (PHYSIOLOGY)

228

Neurochemistry & Neuroendocrinology

(3 units)

Fall

Instructor(s):L. Tecott Prerequisite(s): Neuroscience 201A and 201B, or consent of instructor.

Activities: Seminar: 3 hours

Chemical and molecular mechanisms of synaptic transmission, neurotransmitters, neuroendcricology. Topics may include neurotransmitter metabolism, molecular analysis of synaptic vesicle recycling, cytoskeletal organization of synaptic proteins, circadian rhythms, feeding and drinking, and sexual behavior Offered every three years beginning Fall 2002. (PHYSIOLOGY)

230

Membrane Biophysics & Synaptic Physiology

(3 units)

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Winter

Instructor(s):E. Ullian Prerequisite(s): Neuroscience 201A and 201B, or consent of instructor.

Activities: Seminar: 3 hours

Topics addressed in this course include thermodynamics and kinetics of electrical excitation of nerve, active and passive transport, statistical analysis of synaptic transmission, synaptic and plasticity, and structure/function relations of channel proteins. Offered every three years begining Fall 2000. (PHYSIOLOGY)

235

Sensory Transduction and Perception

(3 units)

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Winter

Instructor(s):J. Korenbrot Prerequisite(s): Neuroscience 201A and 210B, or consent of instructor.

Activities: Seminar: 3 hours

Topics in genetic, molecular and systems approaches to sensory transduction relevant to our understanding of coding of environmental stimuli by sensory neurons will be covered. Offered every three years beginning Spring 2001. (PHYSIOLOGY)

240

Neurobiology of Vision

(3 units)

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Fall

Instructor(s):J. Horton Prerequisite(s): Neuroscience 201A and 201B, or consent of instructor.

Activities: Seminar: 3 hours

Visual information processing by the retina and central nervous system. Molecular, electrophysiological, pharmacological, anatomical and psychophysical approaches will be discussed. Topics may include synaptic interactions, diseases specifc to the visual system, color vision, form perception, motion detection and visual development. Offered every three years beginning Winter 2003. (PHYSIOLOGY)

243

Cognitive Neuroscience

(3 units)

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Winter

Instructor(s):A. Gazzaley Prerequisite(s): NEUROSCI 201A, 301B, 201C or permission of course director.

Restrictions:None. Activities: Seminar: 9 hours

This course will cover research investigating the neural basis of cognition, primarily focusing on neurophysiological studies in humans using MRI, MEG, EEG, and TMS. Topics to be covered include visual perception, attention, memory, sensory and motor control and language. Offered every three years. (NEURSC PRG)

245

Neurobiology of Behavior

(3 units)

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Winter

Instructor(s):Staff Prerequisite(s): Neuroscience 201A and 201B, or consent of instructor.

Activities: Seminar: 3 hours

Lectures and discussion of primary research concerning the neural basis of behavior. Topics will include basic concepts of learning and neuroethology with examples from vertebrate and invertebrate systems. A comparative approach will be taken to understanding psychological constructs such as drive, motivation and emotion. Emphasis is on neural circuit analysis of behaviors such as sound localization, drug self-administration and fear conditioning. Offered every three years beginning Winter 2002. (PHYSIOLOGY)

248

Analysis of Neural and Behavioral Data

(3 units)

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Fall

Instructor(s):L. Frank Prerequisite(s): NS201A and 201B or consent of course director. Previous Matlab experience strongly suggested

Restrictions:None. Activities: Lecture: 1 hours, Seminar: 3 hours

Lectures, critical discussions, and problem solving using Matlab, a mathematical and data visualization program. Topics may include: probability, descriptive statistics, binomial and poisson processes, analysis of spike trains, and analysis of dynamic neural and behavioral dats. Problem sets include statistical analysis and simulation of neural and behavioral data. Previous Matlab experience strongly suggested. Offered every two years beginning Spring 2004 (NEURSC PRG)

249

Neural Circuits, Perception & Action

(3 units)

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Spring

Instructor(s):P. Sabes, S. Lisberger Prerequisite(s): Neuroscience 201A and 201B or consent of instructor.

Restrictions:None. Activities: Lecture: 2 hours, Conference: 2 hours

This advanced course will explore the foundations of Systems Neuroscience via an in-depth study of selected model systems such as sound localization, echolocation, voluntary eye movements, and goal directed reaching. the primary goal of the course is to teach a set of physiological, behavioral and computational primciples and techniques that are broadly applicable in Systems Neuroscience. (PHYSIOLOGY)

250

Research

(1 - 8 units)

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Fall, Winter, Spring, Summer

Instructor(s):Staff Prerequisite(s): Consent of instructor.

Activities: Research: 3 - 24 hours

Dissertation research. (PHYSIOLOGY)